Orientation and the first 6 hallmarks
Readings due before class
Readings should be completed before the actual lecture. The lecture itself is intended to provide a deeper exposition of the material and provide additional insight.
Please read the Resources for the course.
The Hallmarks of Cancer Hanahan and Weinberg (2000) Cell. Volume 100, Issue 1.
- Chapters 1 and 2 of Weinberg, The biology of cancer.
Please make sure that you understand the concept of quiescence and how it differs from normal cell cycle.
Chapter 5 of RA Weinberg, The biology of cancer.
Coller HA (2011) The essence of quiescence. Science.
- Witsch et al. (2010) Roles for growth factors in cancer progression. Physiology
Ensure that you are familiar with the OWL course page.
Using your UWO email acccount, join the Slack workspace at cancer-genetics-uwo.slack.com
Points of reflection
Throughout the course exercises including assignments, exams and projects, it is expected that you have chosen a specific cancer type, a specific pathway or process, and a specific gene. The gene, pathway and process are ideally of special interest in your chosen cancer type.
For example, I might choose invasive ductal breast carcinoma with a focus on Akt-mediated signalling and the Human Epidermal Growth Factor 2 (HER2).
Required reading represents fundamental material that you are expected to master. You can be tested on this material.↩︎