Syllabus

Readings should be completed before each class session. Assignments can be found at at the Assignments page and at OWL. Assignment are submitted using OWL.

Date Number Topic Reading Video Slides+ Assignment Solutions
Sept 13 Lecture 1, Hour 1 M. Hallett; Orientation
Sept 13 Lecture 1, Hour 2 M. Hallett; Sustained proliferative signalling and tumor suppressor genes
Sept 20 Lecture 2, Hour 1 M. Hallett; genome maintenance genes and genomic instability
Sept 20 Lecture 2, Hour 2 M. Hallett; Immortality and Angiogenesis
Sept 23 -- Assignment 1 start
Sept 27 Lecture 3, Hour 1 M. Hallett; Invasion/metastases and Hallmarks II
Sept 27 Lecture 3, Hour 2 M. Hallett; Hallmarks II
Oct 4 Lecture 4, Hour 1 Genomic instablity and Quiz on Cancer Hallmarks (5%)
Oct 4 Lecture 4, Hour 2 Dr. R. DeKoter - Genetic events that affect the immune system and lead to leukemia
Oct 11 Lecture 5, Hours 1 and 2 Dr. Samuel Asfaha; Colon cancer, and how to study the origin of cancers
Oct 14 -- Project proposal due (5%)
Oct 18 Lecture 6, Hour 1 Dr. A. Allan; Role of the lung microenvironment in mediating breast cancer metastasis
Oct 18 Lecture 6, Hour 2 M. Hallett; Hallmarks III: plasticity, epigenetics, senescent cells, microbes
Oct 20 -- Assignment 1 due (15%)
Oct 25 -- Midterm, 1 hour in class (15%)
Oct 30 -- ** Assignment 2 start **
Nov 8 Lecture 7, Hour 1 Dr. Eva Turley; Mutations and microenvironment in tumor initiation
Nov 8 Lecture 7, Hour 2 M. Hallett; Modern bioinformatic tools for cancer/Hallmarks III
Nov 15 Lecture 8, Hour 1 Dr. Vanessa Dumeaux; Interactions between a tumor and the patient microbiome and systemic response
Nov 15 Lecture 8, Hour 2 Dr. Mike Hallett; DNA repair mechanisms
Nov 22 Lecture 9, Hour1 Dr. Joe Mymryk, Virus/host interactions in cancer
Nov 22 Lecture 9, Hour 2 Dr. Saman Malecki, Sensitizing tumors for immune-therapy.
Nov 29 Lecture 10, Hour 1 Dr. Caroline Schild-Poulter; E3 ligases in cancer development and therapeutics
Nov 29 Lecture 10, Hour 2 Dr. Lina Dagnino; Cutaneous squamous cell carcinoma (SCC): epidermal architecture, progenitors, mechanisms of UV-caused SCC
Dec 2 -- Assignment 2 due (15%)
Dec 6 Lecture 11, Hour 1 Dr. Kun Ping Lu; Cell signaling, oncogenes, tumor suppressors, and tumorigenesis
Dec 6 Lecture 11, Hour 2 Dr. Kun Ping Lu; Cancer signaling, tumor microenvironment, and immunotherapy.
Dec 13 -- Project due (20%)
Dec 20, 7pm-9pm HSB 236 -- Final (25%)