| Sept 13 |
Lecture 1, Hour 1 |
M. Hallett; Orientation |
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| Sept 13 |
Lecture 1, Hour 2 |
M. Hallett; Sustained proliferative signalling and tumor suppressor genes |
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| Sept 20 |
Lecture 2, Hour 1 |
M. Hallett; genome maintenance genes and genomic instability |
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| Sept 20 |
Lecture 2, Hour 2 |
M. Hallett; Immortality and Angiogenesis |
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| Sept 23 |
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Assignment 1 start |
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| Sept 27 |
Lecture 3, Hour 1 |
M. Hallett; Invasion/metastases and Hallmarks II |
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| Sept 27 |
Lecture 3, Hour 2 |
M. Hallett; Hallmarks II |
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| Oct 4 |
Lecture 4, Hour 1 |
Genomic instablity and Quiz on Cancer Hallmarks (5%) |
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| Oct 4 |
Lecture 4, Hour 2 |
Dr. R. DeKoter - Genetic events that affect the immune system and lead to leukemia |
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| Oct 11 |
Lecture 5, Hours 1 and 2 |
Dr. Samuel Asfaha; Colon cancer, and how to study the origin of cancers |
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| Oct 14 |
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Project proposal due (5%) |
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| Oct 18 |
Lecture 6, Hour 1 |
Dr. A. Allan; Role of the lung microenvironment in mediating breast cancer metastasis |
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| Oct 18 |
Lecture 6, Hour 2 |
M. Hallett; Hallmarks III: plasticity, epigenetics, senescent cells, microbes |
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| Oct 20 |
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Assignment 1 due (15%) |
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| Oct 25 |
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Midterm, 1 hour in class (15%) |
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| Oct 30 |
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** Assignment 2 start ** |
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| Nov 8 |
Lecture 7, Hour 1 |
Dr. Eva Turley; Mutations and microenvironment in tumor initiation |
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| Nov 8 |
Lecture 7, Hour 2 |
M. Hallett; Modern bioinformatic tools for cancer/Hallmarks III |
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| Nov 15 |
Lecture 8, Hour 1 |
Dr. Vanessa Dumeaux; Interactions between a tumor and the patient microbiome and systemic response |
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| Nov 15 |
Lecture 8, Hour 2 |
Dr. Mike Hallett; DNA repair mechanisms |
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| Nov 22 |
Lecture 9, Hour1 |
Dr. Joe Mymryk, Virus/host interactions in cancer |
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| Nov 22 |
Lecture 9, Hour 2 |
Dr. Saman Malecki, Sensitizing tumors for immune-therapy. |
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| Nov 29 |
Lecture 10, Hour 1 |
Dr. Caroline Schild-Poulter; E3 ligases in cancer development and therapeutics |
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| Nov 29 |
Lecture 10, Hour 2 |
Dr. Lina Dagnino; Cutaneous squamous cell carcinoma (SCC): epidermal architecture, progenitors, mechanisms of UV-caused SCC |
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| Dec 2 |
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Assignment 2 due (15%) |
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| Dec 6 |
Lecture 11, Hour 1 |
Dr. Kun Ping Lu; Cell signaling, oncogenes, tumor suppressors, and tumorigenesis |
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| Dec 6 |
Lecture 11, Hour 2 |
Dr. Kun Ping Lu; Cancer signaling, tumor microenvironment, and immunotherapy. |
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| Dec 13 |
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Project due (20%) |
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| Dec 20, 7pm-9pm HSB 236 |
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Final (25%) |
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