Mutations and microenvironment in tumor initiation

Readings due before class

Required

These are the readings from Dr. Turley

• Bissel MJ, Ines WC (2011) Why don’t we get more cancer? A proposed role of the microenvironment in restraining cancer progression

• Martincorena I et al. (2015) High burden and pervasive positive selection of somatic mutations in normal human skin

• Tian X et al. (2013) High molecular weight hyaluronan mediates the cancer resistance of the naked mole-rat

For the second hour, during my talk:

• Gupta et al. (2019) Phenotypic plasticity as a driver of cancer formation, progression and resistance to therapy

Complementary reading

Action items

• Remember that if you have difficulty accessing these articles, the course web page has advice to use the Western VPN.

Points of reflection